[ Pobierz całość w formacie PDF ]
//-->Handbook ofLaboratory AnimalScienceSecond EditionVolume IEssentialPrinciplesandPracticesEdited byJann Hau and Gerald L. Van Hoosier, Jr.CRC PR E S SBoca Raton London New York Washington, D.C.© 2003 by CRC Press LLCSenior Editor: John SulzyckiProject Editor: Susan FoxProject Coordinator: Pat RobersonCover Designer: Dawn BoydMarketing Manager: Nadja EnglishLibrary of Congress Cataloging-in-Publication DataHandbook of laboratory animal science / edited by Jann Hau, Gerald L. Van Hoosier,Jr.--2nd ed.p. cm.Includes bibliographical references and index.Contents: v. 1. Essential principles and practices.ISBN 0-8493-1086-5 (alk. paper)1. Laboratory animals. 2. Animal experimentation. 3. Animal models in research. I.Hau, Jann. II. Van Hoosier, G. L.QL55 .H36 2002599′.07′24--dc212002031315This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted withpermission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publishreliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materialsor for the consequences of their use.Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical,including photocopying, microfilming, and recording, or by any information storage or retrieval system, without priorpermission in writing from the publisher.All rights reserved. Authorization to photocopy items for internal or personal use, or the personal or internal use of specificclients, may be granted by CRC Press LLC, provided that $1.50 per page photocopied is paid directly to Copyright clearanceCenter, 222 Rosewood Drive, Danvers, MA 01923 USA. The fee code for users of the Transactional Reporting Service isISBN 0-8493-1086-5/03/$0.00+$1.50. The fee is subject to change without notice. For organizations that have been granteda photocopy license by the CCC, a separate system of payment has been arranged.The consent of CRC Press LLC does not extend to copying for general distribution, for promotion, for creating new works,or for resale. Specific permission must be obtained in writing from CRC Press LLC for such copying.Direct all inquiries to CRC Press LLC, 2000 N.W. Corporate Blvd., Boca Raton, Florida 33431.Trademark Notice:Product or corporate names may be trademarks or registered trademarks, and are used only foridentification and explanation, without intent to infringe.Visit the CRC Press Web site atwww.crcpress.com© 2003 by CRC Press LLCNo claim to original U.S. Government worksInternational Standard Book Number 0-8493-1086-5Library of Congress Card Number 2002031315Printed in the United States of America 1 2 3 4 5 6 7 8 9 0Printed on acid-free paper© 2003 by CRC Press LLCThe EditorsJann Hauis Professor in Comparative Medicine at University of Uppsala in Sweden. Dr. Hau graduatedin experimental biology from University of Odense in Denmark after medical and biology studies in1977, and specialized in laboratory animal science. Following research fellowships at University ofOdense, he did his doctorate (Dr. Med) at this university. In 1983, he joined the Department of Pathologyat The Royal Veterinary and Agricultural University (RVAU) in Copenhagen as Associate Professor andHead of the Laboratory Animal Science Unit. He was later Head of the Department of Pathology andDean of the Faculty of Animal Husbandry and Veterinary Science at the RVAU.In 1991, he moved to the Royal Veterinary College (RVC) in London as Professor in the LondonUniversity Chair in Laboratory Animal Science and Welfare. At the RVC, he was responsible for theundergraduate and postgraduate teaching in laboratory animal science and welfare, which included aspecialist Master of Science course in Laboratory Animal Science that attracted a number of postgraduatestudents from many parts of the world.In 1996, Dr. Hau was appointed Professor in Comparative Medicine in Uppsala and Head of a newDepartment of Comparative Medicine. Following amalgamations of departments at the medical faculty,Comparative Medicine is presently integrated with the Department of Physiology of which Dr. Hau ispresently Head. In Uppsala, he has established a number of courses for undergraduate students andpostgraduate students, including specialist education programs.Dr. Hau has organized several international meetings and courses on laboratory animal science. Heis the editor-in-chief of theScandinavian Journal of Laboratory Animal Scienceand editor of thelaboratory animals’ section of the UFAW journalAnimal Welfare.He is a member of a number oflaboratory animal science organizations and former president of the Scandinavian Society of LaboratoryAnimal Science and the Federation of European Laboratory Animal Science Associations.Dr. Hau has supervised many postgraduate master’s students and Ph.D. students and published severalhundred scientific papers and chapters in books. Together with Dr. P. Svendsen, he wrote the first Danishtextbook on laboratory animals and animal experiments published in 1981, 1985, and 1989, and theyco-edited the first edition of theCRC Handbook of Laboratory Animal Sciencepublished in 1994.Dr. Hau’s current research interests include development of refined laboratory animal models forstudies of biological mechanisms in reproductive biology and infections as well as development ofmethods to assess stress and welfare in animals. His research activities also include projects focused onways to replace, reduce. and refine the use of animals in antibody production.Gerald Van Hoosieris Professor of Comparative Medicine in the School of Medicine at the Universityof Washington in Seattle, Washington. Dr. Van Hoosier graduated from the College of VeterinaryMedicine at Texas A&M University at College Station, Texas, in 1957 and subsequently obtainedpostdoctoral training in virology and epidemiology at Berkeley, California, and in pathology at BaylorCollege of Medicine in Houston, Texas. From 1957–1962, he served as a Commissioned Officer in theU.S. Public Health Service assigned to the biologics program at the National Institutes of Health inBethesda, Maryland, where he focused on the development and safety evaluation of poliomyelitis andmeasles vaccine. Following five years in the Public Health Service, Dr. Van Hoosier joined the facultyof the Division of Experimental Biology at Baylor College of Medicine in Houston, Texas, and didresearch on the role of viruses in the etiology of cancer. In 1969, he moved to Pullman, Washington,where he was a faculty member in the Department of Veterinary Pathology in the School of VeterinaryMedicine and Director of Laboratory Animal Resources at Washington State University. He introduceda course on laboratory animals into the third year of the veterinary school curriculum, taught a graduatecourse on the pathology of laboratory animals, and began the development of a series of audio tutorialsin collaboration with the American College of Laboratory Animal Medicine. In 1975, Dr. Van Hoosierwas invited to develop an experimental animal program at the University of Washington. He obtaineda training grant for veterinarians from the National Institutes of Health and established the Departmentof Comparative Medicine, which offers an M.S. degree. He served as the department chairman andAttending Veterinarian until 1995.© 2003 by CRC Press LLCAfter becoming a diplomate of the American College of Laboratory Animal Medicine in 1968, heserved as President in 1977–1978. Other professional activities have included serving as Chairman ofthe Board of Trustees of the American Association for Accreditation of Laboratory Animal Care in1981–1982, President of the American Association of Laboratory Animal Science in 1992, and a memberof the Governing Board of the International Council for Laboratory Animal Science from 1995–1999.In addition to approximately 100 scientific papers, Dr. Van Hoosier was a co-editor ofLaboratoryHamsters,one of a series of texts by the American College of Laboratory Animal Medicine and servedas editor ofLaboratory Animal Sciencefrom 1995–1999. He is currently a member of the EditorialCouncil of theBaltic Journal of Laboratory Animal ScienceandAnimales de Experimentacion.He is the recipient of the Griffin Award from the American Association of Laboratory AnimalScience and a Distinguished Alumni Award from the College of Veterinary Medicine at Texas A&MUniversity.© 2003 by CRC Press LLCContributorsVera BaumansUtrecht UniversityUtrecht, The NetherlandsKathryn BayneAAALAC InternationalRockville, MarylandAndré ChwalibogThe Royal Veterinaryand Agricultural UniversityFrederiksberg, DenmarkPaul deGreeveMinisterie van VWSVeterinair AccountGravenhage, The NetherlandsGilles DemersCanadian Council on Animal CareOttawa, Ontario, CanadaKimberly DrnecJohns Hopkins UniversityBaltimore, MarylandNicole DuffeeWashington University School of MedicineSt. Louis, MissouriHeather ElliottGlaxoSmithKlineHertfordshire, United KingdomRicardo E. FeinsteinThe National Veterinary InstituteUppsala, SwedenMichael F.W. FestingMRC Toxicology UnitUniversity of LeicesterLeicester, United KingdomAlan M. GoldbergJohns Hopkins UniversityBaltimore, MarylandFranziska B. GriederNational Center for Research ResourcesNational Institutes of HealthBethesda, MarylandAxel Kornerup HansenThe Royal Veterinary and AgriculturalUniversityFrederiksberg, DenmarkJann HauUniversity of UppsalaUppsala, SwedenPatricia HedenqvistKarolinska InstitutetStockholm, SwedenLudo J. HellebrekersDepartment of Equine Sciencesand Department Clinical Sciencesof Companion AnimalsUtrecht, The NetherlandsCoenraad HendriksenNational Institute of Public Health andEnvironmentBilthoven, The NetherlandsJack R. HesslerNew York University School of MedicineLaytonsville, MarylandUrban HöglundUppsala UniversityUppsala, SwedenNancy A. JohnstonUniversity of WashingtonSeattle, WashingtonSue KnoblaughUniversity of WashingtonSeattle, WashingtonWarren LadigesUniversity of WashingtonSeattle, Washington© 2003 by CRC Press LLC
[ Pobierz całość w formacie PDF ]